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This case study represents an individual clinician experience with and methodology for using EXPAREL.
Pacira BioSciences, Inc., recognizes that there are other methodologies for administering local anesthetics, as well as individual patient considerations, when selecting the dose for a specific procedure.
Please see Important Safety Information below and refer to the Full Prescribing Information.
Disclosure: Dr Peter O. Newton is a paid consultant for Pacira BioSciences, Inc.
The recommended dose of EXPAREL for infiltration in adults is based on the size of the surgical site, the volume required to cover the area, and individual patient factors that may impact the safety of an amide local anesthetic. The maximum dose of EXPAREL should not exceed 266 mg. The recommended dose of EXPAREL for patients aged 6 to <17 years old is 4 mg/kg, up to a maximum of 266 mg. The recommended dose of EXPAREL in adults for interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and adductor canal is 133 mg. The recommended dose of EXPAREL in adults for adductor canal block is 133 mg (10 mL) admixed with 50 mg (10 mL) of 0.5% bupivacaine HCl, for a total volume of 20 mL.
EXPAREL can be administered unexpanded (20 mL) or expanded to increase volume up to a total of 300 mL (final concentration of 0.89 mg/mL [ie, 1:14 dilution by volume]) with normal (0.9%) saline or lactated Ringer’s solution.
Bupivacaine HCl (which is approved for use in patients aged 12 and older) may be administered immediately before EXPAREL or admixed in the same syringe, as long as the ratio of the milligram dose of bupivacaine HCl to EXPAREL does not exceed 1:2. Admixing may impact the pharmacokinetic and/or physicochemical properties of EXPAREL, and this effect is concentration dependent. The toxic effects of these drugs are additive and their administration should be used with caution, including monitoring for neurological and cardiovascular effects related to local anesthetic systemic toxicity. Other than with bupivacaine, EXPAREL should not be admixed with other drugs prior to administration.
A dual-site bilateral open ESP block is performed after the spinal deformity correction has been completed. A midline incision extending over the levels of planned instrumentation and fusion is performed from T2 to L2 (45 cm). Typical subperiosteal dissection is performed to the tips of the transverse processes as is common for posterior spinal surgery. Self-retaining retractors are placed to expose the spine, translating the paraspinal muscles laterally.
Following the scoliosis instrumentation and bone graft placement, but prior to initiation of wound closure, the EXPAREL injections are made.
The open ESP block is performed by injecting 30 mL in 4 locations (right T5, left T5, right T11, and left T11). A 22-gauge 3-inch spinal needle is placed through the paraspinal muscles from dorsal fascia, just lateral to the previously exposed portion of the transverse processes at the levels noted above. With a fingertip on the transverse process, the needle is directed through the muscle until the needle contacts the unexposed lateral aspect of the transverse process. The needle needs to be at the junction between the transverse process and the rib. Given that the wound is open and much of the transverse process is exposed, locating the needle tip approximately 5 to 10 mm more lateral is straightforward. Then 30 mL of injectate is placed at each of the 4 locations within the erector spinae plane. The dispersion of the injectate can be seen and palpated as it flows proximally and distally within the tissue plane.
Occasionally, the initial dissection of the transverse process violates the ESP and the injectate can be seen leaking into the wound. This should be watched for as the injections are made. Moving the needle more laterally or to an adjacent level may eliminate the leaking into the wound. If these adjustments are not successful, a classic multisite injection with infiltration may be used instead of the ESP block.
The right T5 injection site is shown representing the needle path to the lateral aspect of the T5 transverse process. The starting point for the needle should be lateral to the midline fascial incision and directed through the paraspinal muscle. Administer 30 mL of EXPAREL® (bupivacaine liposome injectable suspension) injectate in all 4 locations (right T5, left T5, right T11, and left T11).
MRI: Yellow highlighting shows the transverse processes where injections are made.
Preoperative and Postsurgical Posterior-anterior (PA) Radiographs
The ESP block injection sites are noted by the yellow circles. The injectate of 30 mL at each site flows proximally and distally through several levels to provide coverage of the entire area of the spinal exposure (blue shaded area).
POSTSURGICAL INSTRUCTIONS INCLUDING PRESCRIPTIONS PROVIDED AND RECOVERY MILESTONES AND GOALS
POD #1 – patient out of bed, sits in chair, begins oral intake—can start on POD #0 if tolerable
POD #2 – drains removed, patient ambulates in room and out of room
POD #3 – patient showers, continues getting up out of bed and ambulating; discharge expected
PATIENT FOLLOW-UP
For more information, please reference the corresponding PDF .
ASP, average sales price; CMS, Centers for Medicare and Medicaid Services.
EXPAREL® (bupivacaine liposome injectable suspension) is indicated to produce postsurgical local analgesia via infiltration in patients aged 6 years and older and regional analgesia in adults via an interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and an adductor canal block. Safety and efficacy have not been established in other nerve blocks.
Please refer to full Prescribing Information.
EXPAREL® (bupivacaine liposome injectable suspension) is indicated to produce postsurgical local analgesia via infiltration
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